Abstract
THE mechanism by which molecules interact with, and so stimulate, the surfaces of olfactory receptor cells has given rise to much speculation. Since oil-soluble substances are often very effective odours, it has been proposed that olfactory transduction occurs when an odorant molecule perturbs the lipids of the sensory membranes. Conversely, the known steric aspects of odorant molecule interactions argue for a more specific binding for which a protein would be a more suitable receptor1–4.
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