Abstract
The trabecular meshwork of three human eyes involved with the exfoliation syndrome were studied. The intraocular tension in the eyes represented successive stages. Exfoliation material was found in all three eyes: In Eye 1 (no glaucoma) only in intertrabecular spaces, in Eyes 2 and 3 also within trabecular beams and in the juxtacanalicular tissue. In addition, abnormal basement membranes were revealed. In Eye 3 (uncontrollable glaucoma), the disorganized trabecular meshwork contained increased amounts of connective tissue elements as well as small vessels. The concept is advanced that the accumulation of exfoliation material in the meshwork impedes aqueous outflow and thus is a pathogenetic factor of importance in glaucoma capsulare.
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