Abstract
Both DNA- and RNA-carrying viruses play a part in the origin of many tumors in animals and may be involved in some types of neoplasia in man. Presently only some RNA viruses and neoplasia will be discussed. Electron microscopy, combined with biophysical, biochemical and biological approach, has laid foundation of present-day knowledge of viruses being causative factors of many types of neoplasia in animals. The appearance, size, internal structure, and mode of development of a number of RNA-viruses in neoplasia are now known. Electron microscopy has either followed or preceded biological studies on causation of neoplasia by viruses. In either case its contribution has been invaluable.Since the observation of virus particles in mammary tumors of mice (Dmochowski, L. : J.Nat.Cancer Inst.15,785 (1954)), they are now known to be the causative agent of this neoplasia. They are widely distributed in milk of various strains of mice and present long before signs of neoplasia appear. Chemical, physical factors and leukemia virus may stimulate mammary tumor virus and lead to mammary neoplasia. Search for similar virus in milk and breast cancer of women revealed structures resembling virus particles.
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