Abstract
Development of measles virus in cultured cells was examined by electron microscopy with ultrathin sectioning and negative staining methods. The cytoplasmic inclusion bodies consisted of helical nucleocapsids which was similar in structure to the nucleocapsid found in measles virions. The cytoplasmic helical nucleocapsid appeared to align beneath the cultured cell membrane, and the membrane differentiated into the internal membrane of the viral envelope and the outer layer of the short projections. The viral particles were released by a budding process involving incorporation into the viral envelope of membrane which was contiguous to but morphologically altered from the membrane of the cultured cells. The intranuclear inclusion bodies were composed of tubular structures similar to those found in the cytoplasmic inclusion bodies. It was inferred that the intranuclear inclusion bodies do not related to the development of the viral particles.
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