Abstract
Aspartate carbamoyltransferase (carbamoyl phosphate:L aspartate Carbamoyltransferase, EC 2.1.3.2), the enzyme catalyzing the first step in pyrimidine biosynthesis, has been localized in nerve cell processes of glutaraldehyde-fixed rat temporal cerebrum. Carbamoyl phosphate is made to react with aspartate. On subsequent hydrolysis orthophosphate is released and precipitated with lead ions. Aspartate Carbamoyltransferase is found in mitochondria of axons and dendrites between the outer and inner membranes and in the cristae. When aspartic acid is either omitted from the reaction mixture or substituted by ornithine, no lead phosphate deposits are found in mitochondria.
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