Abstract
Results are presented of the electron-microscopic examinations of fingernail clippings from 4 patients suffering from Mljet (Mal de Meleda) disease, of 3 obligate heterozygotes of this autosomal recessively inherited disease, as well as of 3 controls. In the nails of the diseased persons, significantly more osmiophilic material was found than in those of controls. In the nails of heterozygotes, the findings were intermediate between those of patients and controls. In the nails of aged persons, a strongly osmiophilic matrix keratin was found. Histochemically, lipids were demonstrated in the ventral plate of diseased nails. The probable significance and implications of these findings are discussed.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.