Abstract
I shall review the work on the electron microscopic determination of base sequence in DNA restricting myself to the approach in which one kind of base is selectively marked. The requirements for success are 1. Appropriate staining reaction: stain must be detectable yet sufficiently compact to allow resolution of adjaconts. Reactions must be sufficiently selective and sufficiently gentle to preserve the.polynucleotide chain. 2. Deposition of polynucleotide chains in untangled and sufficiently extended form. 3. Means for accurately enumerating unmarked bases between the marked ones.
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