Abstract
Changes in ultrastructure and DNA synthesis in retinal cells of prenatal and postnatal developing mice were investigated using electron microscopic radioautography after injection of tritiated thymidine. The labeled cells were located in the middle of the bipolar-photoreceptor layer. Major changes in DNA synthesis and morphology occurred in the first week after birth. Silver grains were observed over the nuclei and mitochondria. A marked difference between labeled and unlabeled cells was detected. The cell organelles were not well developed in the cytoplasm of labeled cells. However, well developed organelles including an intracellular membrane system were distributed throughout the cytoplasm of the unlabeled cells. The different types of cells could be distinguished except some labeled cells. From two weeks onward, the retina structurally matured with the disappearance of labeled cells. The results of this study suggest that cell differentiation in mouse retina is completed two weeks after birth.
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