Abstract
The changes in DNA synthesis of adrenal gland cells in aging mice from prenatal day 19 to postnatal 2 years were observed by electron microscopic radioautography. The percentages of labeled cells (labeling indices) in the zona glomerulosa, zona fasciculata and zona reticularis of the cortex and the medulla after3H-thymidine injection were at their maxima during the perinatal stage and then gradually decreased with age. The ultrastructural features of the cells at the late embryonic and early postnatal stages appeared undeveloped. Well-developed cell organelles, such as smooth surfaced endoplasmic reticulum, mitochondria with tubular or vesicular cristae and lipid droplets, were more frequently observed in the cytoplasm of the unlabeled cells than in the labeled cells in the three zones of the cortex.
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