Abstract
The localization of complex carbohydrates in 41 patients with acute megakaryoblastic leukemia (AMKL) was studied using the periodic acid-thiocarbohydrazide-silver proteinate (PA-TCH-SP) method. Examination by the PA-TCH-SP method revealed that the megakaryoblasts from AMKL had a thick cell coat, a small amount of glycogen, granules and well-developed GERL ofNovikoff. Multivariate analysis revealed no cytochemical differences in the distribution of glycoconjugates in the cytoplasm between AMKL blasts in children and adults, but they were noted between all AMKL blasts and blasts from patients with chronic myelocytic leukemia in megakaryoblastic crisis (CML-MK). The ultrastructural distribution of complex carbohydrates in the blasts from AMKL was extremely different from the acute myelocytic leukemia (AML) blasts as demonstrated by the analysis.
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