Abstract
In acute myocardial ischemia induced by coronary occlusion in the canine heart, mild to moderate ultrastructural changes such as reduction in glycogen granules appeared around 20 min after coronary occlusion. Severe, irreversible alterations, including a mitochondrial dense deposit, appeared after 60 min. With cytochemical study, ATPase activity decreased at 30 min in the sarcoplasmic reticulum (SR) and on the myofibril preceded by activation of acid phosphatase activity in lysosomes and SR. Permeation of lanthanum ion from glycocalyx into the cytosol was observed 30 min after occlusion. These results indicate that activation of acid hydrolases and an inflow of excess Ca++ are likely to be two main causes of ischemic necrosis.
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