Abstract
We are using electron diffraction to characterize a platinum-containing derivative of bacteriorhodopsin, the light-driven proton pump from Halobacterium halobium. This has been undertaken with the dual aims of: 1)using the method of multiple heavy atom isomorphous replacement to obtain high resolution structural information about the protein, and 2)locating heavy atom labelled amino acids in the structure in order to correlate the recently determined sequence with the structural map. A necessary first step in such studies is the location of the heavy atoms in the low resolution structure. This report focusses on ways of dealing with the inherent statistical uncertainties encountered in this heavy atom localization.
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More From: Proceedings, annual meeting, Electron Microscopy Society of America
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