Electron-conformational transformations in nanoscopic RyR channels governing both the heart’s contraction and beating

Abstract

We show that a simple biophysically based electron-conformational model of RyR channel can explain and describe on equal footing the oscillatory regime of the heart’s cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca2+ sarcoplasmic reticulum overload.