Abstract
A method for the determination ofmethindione (2-ethyl-2-methylaminoindandione-1,3) in human serum is described. The drug and a homologue as internal standard are extracted into toluene from alkaline serum and the extract is analyzed by electron capture gas chromatography. The sensitivity limit with a 2-ml sample was about 1 ng/ml. Recoveries at the 50 ng level were 100 + 3% Results from oral administration of a methindione solution are given. The minimum detectable quantity (MDQ) for methindione is 3.6·10 -16 mole/sec. which implies that most drugs with the conjugated β-diketone structure are suitable for electron capture detection.
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