Abstract
AbstractThe aging population increased the demand for the development and utilization of bone filling materials. In this study, hydroxyapatite (HAP) and graphene oxide (GO) were introduced into thermoplastic polyurethane (TPU) by melt mixing and electron beam radiation to obtain the new hot melt adhesive (TPU/HAP/GO). The structures and morphologies of the TPU/HAP/GO were analyzed using FTIR, XRD, SEM, BET, DSC. The mechanical properties of the TPU/HAP/GO were evaluated using a universal testing machine. TPU/HAP/GO was demonstrated to have good bacterial inhibition by the zone of inhibition test and plate method. The good biocompatibility of the hot melt adhesive was demonstrated using the MTT method and the Hoechst 33342/PI double staining method. The osteogenic differentiation of mouse osteoblasts (MC3T3‐E1) treated with TPU/HAP/GO was detected by alkaline phosphatase (ALP) staining. ALP staining showed that the hot melt adhesive promoted the differentiation of MC3T3‐E1 cells into osteoblasts. This hot melt adhesive had great application potential in bone tissue engineering.Highlights Green electron beam radiation method for synthesizing hot melt adhesives. Enhanced mechanical properties of composites by incorporation of graphene oxide. Improvement of antimicrobial and osteogenic capacities for polyurethane.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
