Abstract
Aim: Electromembrane extraction (EME) of 37 drugs of abuse with significant differences in terms of polarity (0.68<log P <4.3) and basicity (1.17<pKa<10.38) was investigated from human plasma. Materials & methods: EME was performed with 250mM trifluoroacetic acid and DMSO (1:1 v/v) in the acceptor solution. Results & conclusion: The analytes were extracted efficiently with pure 2-nitrophenyloctyl ether as supported liquid membrane when the acceptor solution was modified with DMSO. Thus, using DMSO mixed with 250mM trifluoroacetic acid (1:1, v/v) as acceptor solution, recoveries from 40 to 105% (relative standard deviation<20%) were obtained for 33 of the analytes under optimized conditions. EME followed by ultra-HPLC-MS/MS analysis was evaluated from human plasma, and the results were satisfactory.
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