Abstract
Liquid crystal elastomers (LCEs) are unique among shape-responsive materials in that they exhibit large and reversible shape changes and can respond to a variety of stimuli. However, only a handful of studies have explored LCEs for biomedical applications. Here, we demonstrate that LCE nanocomposites (LCE-NCs) exhibit a fast and reversible electromechanical response and can be employed as dynamic substrates for cell culture. A two-step method for preparing conductive LCE-NCs is described, which produces materials that exhibit rapid (response times as fast at 0.6 s), large-amplitude (contraction by up to 30%), and fully reversible shape changes (stable to over 5000 cycles) under externally applied voltages (5-40 V). The electromechanical response of the LCE-NCs is tunable through variation of the electrical potential and LCE-NC composition. We utilize conductive LCE-NCs as responsive substrates to culture neonatal rat ventricular myocytes (NRVM) and find that NRVM remain viable on both stimulated and static LCE-NC substrates. These materials provide a reliable and simple route to materials that exhibit a fast, reversible, and large-amplitude electromechanical response.
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