Abstract
Summary Data on physiologic alteration in dogs undergoinggeneral body cooling and rewarming are presented. Heart rate, mean arterial pressures, platelets and white cell counts all showed significant decreases at low temperature levels (22° to 25°C.). Serum potassium concentrations were foundto be greatly increased just prior to ventricular fibrillation in the cold state. Prolonged acidosis or alkalosis did not alter this elevation. Electrocardiographic patterns were fairlyconstant with deep cooling and could be used to predict impending difficulty. It is suggested that a relative tissue hypoxia associated with low coronary flow is a factor in the production of ventricular fibrillation during profound hypothermia.
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