Electrohydrodynamic atomization, a promising avenue for fast-dissolving drug delivery system: Lessons from tadalafil-loaded composite nanofibers

doi:10.7324/japs.2020.101005

Abstract

Highlights

Tadalafil, an oral selective phosphodiesterase-5 inhibitor (PDE-5), recognized officially in the year 2000 and approved by the Food and Drug Administration (FDA) for the management of erectile dysfunction (ED) (Brock et al, 2002)
The well-known solubility enhancement ability of PVP is employed for aiding in tadalafil dissolution development in the nanofibers formulation prepared
The secondary polymer used is polyethylene oxide (PEO) due to its semi crystallinity which minimizes the hygroscopic nature of the composite nanofibers fiber-forming capability at low concentration with its hydrophilic property and compatibility

Summary

Introduction

An oral selective phosphodiesterase-5 inhibitor (PDE-5), recognized officially in the year 2000 and approved by the Food and Drug Administration (FDA) for the management of erectile dysfunction (ED) (Brock et al, 2002). Strategies concerned with the solubility and dissolution enhancement of class II drugs define the borders of promising research area (Vemula et al, 2010). Techniques developed to improve the solubility of tadalafil as an attempt for enhancing its oral bioavailability include, cocrystal (Vinesha et al, 2016), complexation (Badr-Eldin et al, 2008), liquisolid compacts. Fast dissolving drug delivery system has become an important strategy for drug delivery application as it enhances drug solubility, onset of action, and bioavailability. The lenience of the fabrication process is achieved through a high distribution of the main components in the filament polymer matrix upon electrospinning. The collected fibers characteristics depend on various variables including polymers type and properties, solution viscosity, solvent system, distance in between, voltage applied, and humidity (Huang et al, 2003)

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