Abstract
Objective. To identify electroencephalographic predictors of symptomatic seizure in children and adolescent with lymphoid tumors during chemotherapy.Material and methods. EEG results of a study in 20 children aged 7 to 15 years with lymphoid tumors during chemotherapy under the В-NHLBFM-90/95 и ALL IC-BFM 2002 program are presented. Depending on the presence of clinical manifestations, patients were divided into groups: 1st group (n = 10 without epileptiform signs), 2nd group (n = 10 with epileptiform signs).Results. In patients of group 1, who did not have clinical manifestations (seizures), the EEG recorded a signifiantly better, compared with patients of group 2, spectral dencity in band alpha rhythm and sensorimotor rhythm (p < 0.001) and signifiantly less delta activity and beta frequencies (p < 0.001). It was found that, despite the absence of epileptiform signs in the EEG, these patients had fewer EEG correlates of the ‘spike-wave’ complexes, and signifiantly less power levels of delta and beta-2 frequency bands (p < 0.001).Conclusions. The use of comparative EEG mapping made it possible to identify predictors of epileptiform activity in children and adolescents with lymphoid tumors during chemotherapy.
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