Abstract
BackgroundFunctional magnetic resonance imaging studies of resting-state functional connectivity have shown that major depressive disorder (MDD) is characterized by increased connectivity within the default mode network (DMN) and between the DMN and the frontoparietal network (FPN). However, much remains unknown about abnormalities in higher frequency (>1 Hz) synchronization. Findings of abnormal synchronization in specific frequencies would contribute to a better understanding of the potential neurophysiological origins of disrupted functional connectivity in MDD. MethodsWe used the high temporal resolution of electroencephalography to compare the spectral properties of resting-state functional connectivity in individuals with MDD (n = 65) with healthy control subjects (n = 79) and examined the extent to which connectivity disturbances were evident in a third sample of individuals in remission from depression (n = 30). Exact low resolution electromagnetic tomography was used to compute intracortical activity from regions within the DMN and FPN, and functional connectivity was computed using lagged phase synchronization. ResultsCompared to control subjects, the MDD group showed greater within-DMN beta 2 band (18.5–21 Hz) connectivity and greater beta 1 band (12.5–18 Hz) connectivity between the DMN and FPN. This hyperconnectivity was not observed in the remitted MDD group. However, greater beta 1 band DMN–FPN connectivity was associated with more frequent depressive episodes since first depression onset, even after controlling for current symptom severity. ConclusionsThese findings extend our understanding of the neurophysiological basis of abnormal resting-state functional connectivity in MDD and indicate that elevations in high-frequency DMN–FPN connectivity may be a neural marker linked to a more recurrent illness course.
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More From: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
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