Abstract
The ip administration of l-glutamate was found to induce clonic movements and tonic-clonic seizures in rats at a dose level of 2.0 mmole/100 g body weight. The susceptibility to the seizures was not affected by dietary pyridoxine deficiency. The seizure episodes were characterized by 3–5 cps high amplitude spikes ranging from 200 μV/cm to 1000 μV/cm. In the interseizure periods records showed 1 cps high voltage slow waves. The results are discussed in terms of possible biochemical mechanisms operative in the glutamate induced seizures.
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