Electroencephalographic Slow-Wave Activity During Sleep in Different Phases of Blood Pressure and Respiration Oscillations.

Abstract

Sleep is characterized by dynamic coupling between central (CNS) and peripheral autonomic (ANS) nervous systems. However, further research is needed to better understand the multiple interactions occurring among electroencephalographic (EEG) features and respiratory and cardiovascular (CV) outputs modulated by the ANS during sleep. Here, we developed new methods to study EEG slow-wave activity (SWA) during non-rapid eye movement (NREM) sleep with respect to the phases of peripheral oscillations. EEG, respiration, and continuous blood pressure signals recorded from 20 participants were analyzed. Digital filters, designed to decompose the signals into different frequency bands, and the Hilbert transform were applied to estimate the instantaneous phases and frequencies of the peripheral oscillations. The peripheral oscillations were categorized into four phases representing up and down states. EEG delta power (synchronized SWA) was computed and compared across these phases during NREM sleep. Results show that EEG delta power is higher during down phases of slow and respiratory frequency components of blood pressure and during up phases of respiration, suggestive of CNS-ANS coupling during NREM sleep. The developed techniques provide the preliminary framework to further analyze and interpret complex interactions between cortical and cardiac oscillations and their synchrony.