Abstract

The effects of intracentral injection of antibodies against brain-specific S-100 antigen (S-100 protein) were studied by an electroencephalographic method with estimation of the power of the EEG rhythms by analog computer. Intracerebral injections of antibodies against S-100 protein caused an increase in power of the principal EEG rhythms in the hippocampus, caudate nucleus, and mesencephalic reticular formation, followed by the development of epileptiform activity in these same structures.

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