Electrodeposition of CuO from Cu-MOF on glassy carbon electrode: A non-enzymatic sensor for glucose

Abstract

The present study describes the fabrication of copper oxide (CuO) on glassy carbon (GC) electrode by electrodeposition method using Cu-MOF. The CuO modified GC electrode exhibits a sharp anodic peak at −0.07V corresponding to the oxidation of Cu to Cu oxide and a cathodic peak at −0.18V corresponding to the reduction of Cu oxide. Then, the CuO modified electrode was exploited for the determination of glucose. It was optimized with respect to different concentrations of Cu-MOF, applied potential and deposition time. The GC electrode modified with CuO using 8mg/mL of Cu-MOF at an applied potential of −0.30V for 300s showed higher electrocatalytic activity towards glucose by shifting its oxidation towards less positive potential but also enhanced its oxidation current. The amperometric response of glucose was increased linearly while increasing its concentration from 500nM to 5mM and the limit of detection was found to be 70nM (S/N=3). Finally, the application of the present method was exhibited by determining glucose in human blood serum sample. Further, the present method of glucose determination was validated with the commercially available glucometer.