Electrodeposition of alginate with PEDOT/PSS coated MWCNTs to make an interpenetrating conducting hydrogel for neural interface

Abstract

Neural interface is a critical component for the communication between the central nervous system and outside devices. But neural tissues withstand constant mechanical activity with outside devices which aggravates inflammation response. The investigation about soft interfacial modification materials for neural implants is a promising way to reduce the mechanical mismatch of neural tissues and implants. In this study, soft alginic acid gel and poly(3, 4-ethylenedioxythiophene)/poly(styrene sulfate)(PEDOT/PSS) coated multi-walled carbon nanotubes(MWCNT) was co-deposited on a microwire neural electrode, then PEDOT/PSS was electrochemically grown through the coating material to form a kind of soft interpenetrating networks (IPNs) for the improvement of neural interface. Compared to unmodified electrodes, the modified electrodes possess higher charge storage capacity (CSC) and lower electrochemical impedance, which would benefit the performance of stimulating and recording respectively. The IPNs are very soft after reswelling in brain tissue, and the cell experiment indicate its fantastic biocompatibility. Furthermore, acute neural recording experiments revealed that the IPNs reduced the noise floor. All these characteristics are greatly desired for the neural interface. Overall, we developed a soft interpenetrating conducting hydrogel coating material on the neural interface with excellent electrical and biological performance.