Electrode Reaction of Adriamycin Interpreted as Two Consecutive Electron Transfers with Stabilization of the Intermediate

Abstract

In cyclic voltammetry of adriamycin (doxorubicin hydrochloride) adsorbed on graphite electrode surface, the response of quinone/hydroquinone redox centers is split into two pairs of peaks because of inactivation of semiquinone intermediates by the hydrogen bonds.