Electrochemistry of omeprazole, active metabolites and a bound enzyme model. Possible involvement of electron transfer in anti-ulcer action

Abstract

Electrochemical studies were performed with omeprazole, active metabolites and a bound enzyme model. The active metabolites, cyclic sulfenamide and sulfur radical entities, exhibited reduction potentials of −0.3 V and −0.2 V respectively. The value for the bound enzyme model was −0.7 V and that for omeprazole was > −1.4 V. The results lend credence to the hypothesis that electron transfer comprises part of the mode of action in addition to (H +/K +) ATPase inhibition.