Abstract
Electrochemical sensor was fabricated for determination of dobutamine (DB) based on gold nanoparticles/cobaltphthalocyanine modified carbon paste electrode AuCoPcCPE. Two components in the composite structure contribute to the faradaic signal at the interface of the electrode: conduction of Au-nano-centers and charge mediation through cobalt-phthalocyanine moieties. The proposed sensor exhibited excellent performance for the determination of DB in human urine samples with satisfying recovery results. Low detection limit of 0.84 × 10−7 mol L−1 in the linear dynamic range of 6.0 × 10−6 mol L−1 to 2.0 × 10−4 mol L−1 was obtained at the AuCoPcCPE sensor. It was possible to simultaneously and selectively determine DB in each of the following mixtures: DB/Morphine, DB/paracetamol using the AuCoPcCPE sensor. The proposed sensor exhibited high reproducibility, enhanced sensitivity, selectivity, and unique stability.
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