Abstract

An electrochemiluminescence (ECL) based on energy transfer from electro-generated triplet sulfur dioxide to pipemidic acid (PPA) was studied. A weak ECL from triplet sulfur dioxide 3 SO 2 ∗ was observed when sulfite was electrochemically oxidized in sulfuric acid solution on a Pt electrode. When PPA was present, the weak ECL was enhanced. The enhanced ECL was attributed to energy transfer from 3 SO 2 ∗ to PPA. Based on the enhanced ECL, a flow-injection (FIA) ECL method for the determination of PPA was proposed. The proposed method allowed the measurement of PPA over the range of 1.0 × 10 −7 to 2.0 × 10 −5 mol l −1. The detection limit was 3.9 × 10 −8 mol l −1, and the relative standard deviation for 1.0 × 10 −6 mol l −1 PPA ( n = 9) was 1.3%. This method was evaluated by the analysis of PPA in pharmaceutical preparations and urine samples.

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