Abstract
In this study, we present a simple, sensitive and selective analytical procedure for the ibuprofen (IBP) analysis using the commercially available screen-printed carbon electrode electrochemically activated (aSPCE) by cyclic voltammetry in 0.1 M NaOH. The quantitative determinations of IBP were carried out in 0.25 M acetate buffer solution of pH 4.5 ± 0.1 using the differential-pulse voltammetry (DPV). Different experimental parameters for DPV analysis were optimized, including pH and concentration of supporting electrolyte, amplitude (ΔEA), scan rate (ν) and modulation time (tm). The linear ranges of calibration curve were from 0.50–20.0 and 20.0–500.0 µM. The detection and quantification limits were estimated to be 0.059 and 0.20 µM. The aSPCE displayed satisfactory repeatability, reproducibility, and selectivity. Furthermore, the DPV procedure with the use of aSPCE was used to determination of IBP in pharmaceutical formulations. The results achieved by DPV show satisfactory agreement with those obtained by manufacturers (the relative errors are in the range of 3.1–4.7%).
Highlights
Ibuprofen, 2-(4-isobutyphenyl)propionic acid is one of the important nonsteroidal anti-inflammatory drugs (NSAIDs) commonly prescribed for treatment of chronic and acute pain and many rheumatic and musculoskeletal disorders
cyclic voltammograms (CVs) indicated the presence of one peak in the anodic run
We found that the electrochemical activation of the electrode surface using CV in 0.1 M NaOH resulted in changes in its morphology and a decrease in the charge transfer resistance, which translated into a significant increase in the rifam
Summary
2-(4-isobutyphenyl)propionic acid is one of the important nonsteroidal anti-inflammatory drugs (NSAIDs) commonly prescribed for treatment of chronic and acute pain and many rheumatic and musculoskeletal disorders. It is used in case of fever symptoms [1,2,3]. Ibuprofen works by non-selective inhibition of cyclooxygenase-1. While its anti-inflammatory properties can be weaker than those of some other NSAIDs, it has a prominent analgesic and antipyretic role. Ibuprofen is available as tablets with an active substance content of 200 to 800 mg Its effects are due to the inhibitory actions on cyclo-oxygenases, which are involved in the synthesis of prostaglandins involved in production of pain, inflammation and fever [4].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
