Electrochemical Three‐Component Reaction to Construct N‐(α‐alkoxyalkyl)benzotriazoles

Abstract

AbstractN‐(α‐alkoxyalkyl)benzotriazoles are of great importance for biochemical and antitumor activity. A feasible protocol has been developed for the synthesis of N‐(α‐alkoxyalkyl)benzotriazoles using azoles, aldehydes and alcohols as substrates under electrochemical conditions. The reaction is carried out under acid catalyst‐ and oxidant‐free conditions, so that a variety of synthetically useful nitrogen heterocyclic derivatives can be obtained. More meaningfully, a gram‐scale synthetic approach was employed to demonstrate the scale‐up applicability of this transformation.