Electrochemical Synthesis and Reactivity of Three-Membered Strained Carbo- and Heterocycles.

Abstract

Three-membered carbocyclic and heterocyclic ring structures are versatile synthetic building blocks in organic synthesis with biological importance. Moreover, the inherent strain of these three-membered rings leads to their ring-opening functionalization through C->C, C->N, and C-O bond cleavage. Traditional synthesis and ring-opening methods for these molecules require the use of acid catalysts or transition metals. Recently, electro-organic synthesis has emerged as a powerful tool for initiating new chemical transformations. In this review, the synthetic and mechanistic aspects of electro-mediated synthesis and ring-opening functionalization of three-membered carbo- and heterocycles are highlighted.