Abstract
A PSS/nano-ZnS thin film modified electrode has been fabricated on the surface of glassy carbon electrode (GCE). In pH 5.0 phosphate buffer solution (PBS), Ofloxacin (OFX) appeared as an anodic peak with the peak potential of 1.28 V at PSS/nano-ZnS film modified electrode. In comparison with a bare GCE or a nano-ZnS modified electrode, the PSS/nano-ZnS film modified electrode exhibited an enhanced effectiveness for the oxidation of OFX. Cyclic voltammetry (CV) coupled with fluorescence and UV-vis absorbance spectra techniques were used to study the interaction of OFX with Calf thymus DNA (ctDNA). The interaction of OFX and ctDNA could result in a considerable decrease in the peak currents and positively shift in the peak potential, as well as changes of fluorescence, UV-Vis adsorption spectra. All acquired data showed that the new adduct between OFX and ctDNA was formed.
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