Electrochemical sensor using cobalt oxide-modified porous carbon for uric acid determination.

Abstract

An electrochemical sensor for the detection of uric acid was constructed using cobalt oxide-modified porous carbon@multi-walled carbon nanotube (MWCNTs) composite material for the modification of theelectrode. Firstly, ZIF-67 is generated on carbon nanotubes using thesurfactant cetylammonium bromide (CTAB) as template. The vesicles generated by CTAB act as nucleation sites for the in situ growth of ZIF-67. Then, cobalt oxide-modified porous carbon was obtained after high-temperature carbonization of ZIF-67, leading to the formation of cobalt oxide-modified porous carbon@MWCNT composite materials. Co-N and Co-O active sites on the composite material can improve the oxidation of uric acid on the electrode surface, leading to enhanced sensitivity and selectivity for uric acid detection. The sensor has a good linear range from 1 to 40 μM for uric acid detection with a detection limit of 0.09 μM. The sensor was utilized for determination of uric acid in actual serum samples.