Electrochemical Sensing of Triazole Drugs based on Carbon Based Nanocomposites: A Review

Abstract

India is the nation with international boarder wherein a huge number of soldiers are deployed. Fungal infections are a common complaints suffered by military personnel at warm, damp or wet environments. Anti-fungal drugs have their application in the treatment of fungal infections. They do so by either killing or controlling the fungi in the host with low toxicity. The Heterocyclic compounds with triazole linkages are known for their effective anticancer and antifungal properties. The sensitive, robust, reproducible quantification of triazole can take place at fast rates without any involvement of multiple steps of sample preparation. This is all possible because of the electrochemical activity of the triazole. There has been a significant increase in Carbon-based nanomaterials being preferred for sensor materials development. The properties of Carbon-based nanomaterials such as inherent electrical conductivity, chemical stability, strong adsorption capacity, and good biocompatibility are what make it preferable. The materials with these properties include an array of carbon compounds such as carbon nanotubes (CNTs), fullerenes, carbon nanofibers, carbon black, etc. CNTs are often counted in the list of important carbonaceous materials and they're also suitable for the fabrication of the electrodes. This is possible because of its high surface area, and good electrical properties. The materials based on CNTs are used to produce sensors that are hybrid in nature, drug delivery, and high-performance composites for plants to identify pathogens. Methods based on high performance liquid and thin layer chromatography, gas chromatography and spectrophotometry involves a series of sample preparations and are executed over costly equipments. Owing to numerous advantages such as rapid response, high performance, cost effective, high sensitivity and selectivity, electrochemical sensors became increasingly promising tool over other conventional analytical methods. Nanohybrid based electrochemical sensor is used for trace level estimation of triazole drugs in pharmaceutical dosage and biological samples.