Abstract
Artemisinin is a naturally occurring sesquiterpene lactone with an endo-peroxide bond. This drug is used for treatment of many diseases including malaria. The reduction of this molecule on an electrode surface was carried out by cyclic voltammetry as well as amperometry. Cyclic voltammetry of artemisinin generated one prominent peak wave at -1.0 V and another, smaller one at -0.3 V vs Ag/AgCl reference electrode. The bulk electrolysis of artemisinin on a carbon electrode generated two other irreversible peak waves at around -0.7 and -0.1 V. The concentration of the products was dependent on the time of electrolysis. LC-MS was used to determine the bulk electrolysis products of artemisinin. Initially dihydroartemisinin was generated as the main reduction product. Other reduction products were formed after further reduction of dyhidroartemisinin.
Highlights
Artemisinin is a commonly used drug for the control of malaria [1]
Separation of bulk electrolysis reduction products were carried out using ZORBAX C-18 300SB column (4.6 150 mm) and with 3.5 μm particle size, Agilent Technologies
We have studied the bulk electrolysis of ART and attempted to assign molecular structures of possible products
Summary
Artemisinin is a commonly used drug for the control of malaria [1]. It occurs naturally and can be extracted from artemisia flowers. The mature artemisia flowers are gold tainted and together with the seeds have strong anti-malaria effect. Even when a small number of flowers are left in a glass of water for some time at room temperature, a delayed extraction of ART takes place, capable of malaria prevention. These flowers provide a strong treatment for malaria attack in remote areas, where anti malaria drugs are not available. Malaria is a devastating disease that kills many people every year
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