Abstract
A systematic investigation of the preparation, characterization, and use of lithium phthalocyanine (LiPc) microcrystalline powder as a probe for electron paramagnetic resonance (EPR) oximetry applications has recently been initiated (Ilangovan et al. J. Phys. Chem. B 2000, 104, 4047−4059). Electrochemical preparation of LiPc under potentiostatic conditions (+0.4 V) yielded microcrystalline paramagnetic particles that showed extremely narrow (<10 mG) and oxygen-dependent EPR line width measured at 9.82 GHz (Ilangovan et al. J. Phys. Chem. B 2000, 104, 9404−9410). In this report, we demonstrate the application of this material to measure oxygen concentration in a biochemical (xanthine/xanthine oxidase, X/XO), cellular (human polymorphonuclear neutrophils, PMNs), and in vivo (mice) biological systems. The microcrystalline particles showed high oxygen-sensitivity and stability in aqueous and physiological environments. The particles implanted in the gastrocnemius muscle of living mice were found to be stable ...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
