Electrochemical Oxidative Functionalization of Pyrazolin‐5‐ones: Access to 4‐Quinoxalinone‐Substituted Pyrazoles

Abstract

A strategy for the preparation of 4‐quinoxalinone‐substituted pyrazole derivatives by electrochemical functionalization of pyrazolin‐5‐ones is reported. Quinoxalinones, possessing significant biological activities, serve as aryl sources and participate in the transformation under electrochemical conditions without the necessity of adding extra oxidants and catalysts. This method features one‐pot synthesis, scale‐up and late‐stage functionalization of bioactive molecule derivatives. Notably, activity testing reveals that some compounds exhibit superior inhibitory effects on the proliferation of A549 cells compared to 5‐fluorouracil.