Abstract
Edoxaban (EDX) electrooxidation was investigated at a carbon paste electrode using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry (CA). Several experimental conditions were evaluated, including buffer solution, pH, concentration, and scan rate. The results indicated that the redox process was irreversible over the pH and scan range studied and exhibited a diffusion-controlled behaviour. Furthermore, the drug was subjected to bulk electrolysis followed by UHPLC-QTOF/MS to elucidate the mechanism behind its electrooxidation. The present study also demonstrated the electroanalytical method’s ability to successfully determine EDX in pharmaceutical formulations and human serum without interference from the leading excipients and biological constituents. The obtained analytical curves exhibited two linear ranges, from 1.2 × 10−6 to 1.2 × 10−5 mol/L and from 1.4 × 10−5 to 7.4 × 10−5 mol/L, with a sensitivity of 0.068 μA (μmol/L)−1 and a limit of detection (LOD) of 2.6 × 10−7 mol/L, at a relative standard deviation (RSD) of 2.96 %.
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