Abstract
Curcuminoids, reported to have important biological properties, such as antioxidant, anti-Alzheimer, and antidiabetic properties, comprise curcumin (CRM; 1,7-bis [4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) and its derivatives demethoxycurcumin (DMC; (E,6E)-1-(3,4-dimethoxy-cyclohexyl)-7-(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5- dione) and bisdemethoxycurcumin (BDMC; 1,7-bis[4-hydroxyphenyl]-1,6-heptadiene-3,5-dione). Their electrochemical oxidations are thoroughly explored by applying cyclic and differential pulse voltammetric techniques. The dependence of current intensities and potentials on pH, concentration, scan rate, and nature of the buffer was investigated. The outcome is supported by density functional theory computations indicating the transfer of 4-e /H+ , 6-e /H+ , and 8- e /H+ couples involved in the oxidation mechanisms of CRM, DMC, and BDMC, respectively, leading to the formation of the same oxidized product.
Highlights
In ancient times, natural products were the basis of traditional medicine. 1 They still play an important role in the drug discovery field due to their close linkage to promising medicinal applications
Curcuminoids have been reported as antioxidant, anti-Alzheimer, antidiabetic, antimicrobial, antiinflammatory, and anticancer agents. 2−5 All these properties endow curcuminoids with important clinical applications and distinctive attributes in the search for new drugs
It is necessary to reveal the respective quantities of each curcuminoid in turmeric samples as the activities of curcuminoids may differ
Summary
Natural products were the basis of traditional medicine. 1 They still play an important role in the drug discovery field due to their close linkage to promising medicinal applications. 12 proposed the mechanism for the electrochemical oxidation of CRM involving the transfer of 4 electrons and 4 protons (4-e − /H + couple) to furnish a hexaoxo product (2), which contains two intact MeO units (Scheme 1).
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