Abstract
Electrochemical detection of specific DNA sequence was investigated by using a gold electrode immobilized with probe DNA and tris(1, 10-phenanthroline) cobalt (II) complex (Co(phen)32+) as a hybridization indicator. 25-mer probe DNA modified with a thiol group at 5' end was immobilized on a gold electrode. After the probe DNA-modified gold electrode was hybridized with complementary target DNA, the anodic peak current of 0.1mM Co(phen)32+ increased as to the concentration of target DNA in the range from 10-7M to 10-4M. On the other hand, no current increase was observed when it was hybridized with poly-deoxy A as non-complementary DNA in the same range of concentration.
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