Electrochemical non-enzymatic glucose sensors based on CuO nanostructures

Abstract

Accurate and convenient blood glucose detections are important for controlling diabetes and its complications. The rapid development of nanomaterials and chemical synthesis technology has greatly contributed to the advancement of glucose sensors, and portable and non-invasive detections have become a new development direction. Electrochemical sensors with fast analysis time, high sensitivity and good selectivity have shown great attraction in glucose detection and have become one of the most promising sensors. While the design and combination between enzymes and electrodes have promoted the flourishing development of enzyme-based sensing platforms, the more stable physicochemical properties of non-enzymatic sensing methods have attracted wide interests. The design and application of non-enzymatic sensors based on noble metals, transition metals and composites have made tremendous progress. Carbon and organic materials have also been used for the immobilization of non-enzymatic sensing materials and the improvement of conductivity of sensors. This article reviewed the development of electrochemical enzymatic and non-enzymatic glucose sensors, and discussed in detail the development and study of non-enzymatic glucose sensors based on the design of morphology, structure and composites of CuO. Finally, the prospects and challenges of electrochemical non-enzymatic sensors based on CuO nanostructures were proposed.