Abstract
Objective To study the electrochemical behavior of bupivacaine hydrochloride and to establish an electrochemical method for determination of bupivacaine hydrochloride.Methods The electrochemical behavior of bupivacaine hydrochloride was studied by cyclic voltammetry(CV),and differential pulse voltammetry(DPV)was used to determine the contents of bupivacaine hydrochloride.Results In a 0.01 mol/L tetrabutylammonium perchlorate(TBAP)buffer solution,the oxidization peak current on the platinum electrode in the bupivacaine hydrochloride solution was in a good linear relation over a concentration range of 1.0×10-5-2.0×10-4 mol/L,with the r value being 0.995 8,and a detection limit of 1×10-5 mol/L(by DPV).Conclusion Our method is accurate,easy to perform,and with good repeatability,and it can be used to determine bupivacaine hydrochloride content in bupivacaine hydrochloride raw medicine.
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More From: Academic Journal of Second Military Medical University
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