Abstract
AbstractTo develop an electrochemical detection method for COVID‐19, we have investigated the interaction between RG‐1, a characteristic parallel four‐strand RNA component of the COVID‐19 genome, and cyclic ferrocenylnaphthalene diimides carrying different linker lengths 1 and 2, which bind to RG‐1 more strongly than cyclic naphthalene diimide 3 that lacks a ferrocene moiety. In particular, the binding affinity of 1 having short one showed the highest binding affinity to RG‐1, and the redox current of 1 increased in the presence of RG‐1 using a glassy carbon electrode. This increasing current of 1 in the presence of c‐myc as a parallel G4 DNA or single‐stranded RNA was lower than that in the presence of RG‐1. Several RG‐1 was electrochemically detected at the nanomolar level by 1.
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