Abstract
Electrochemical characterization of ascorbic acid oxidation on a graphite screen printed electrode (SPE) modified with La3+/Co3O4nanocubes is performed by applying cyclic voltammetry (CV), chronoamperometry (CHA), and differential pulse voltammetry (DPV) techniques. Synthesized La3+/Co3O4nanocubes for SPE modification, La3+/Co3O4/SPE, enhance the ascorbic acid electrooxidation kinetics by reducing the anodic overpotential. Excellent La3+/Co3O4/SPE electrochemical properties provide sensitive ascorbic acid voltammetric determination with low detection limit, good stability and quick response towards electrooxidation of ascorbic acid as compared to bare SPE. Under optimized conditions, DPV current demonstrates a linear response for ascorbic acid over a concentration range of 1.0 to 900.0 mM with a correlation coefficient of 0.9997, and detection limit (LOD) (S/N = 3) = 0.3 mM. The proposed procedure offers a potential application for producing the sensor with good repeatability. Also, fast response of fabricated sensor can allow a real-time analysis of real samples.
Highlights
IntroductionAscorbic acid is a water soluble vitamin (vitamin C), widely present in many biological systems, fruits and vegetables
Ascorbic acid is a water soluble vitamin, widely present in many biological systems, fruits and vegetables
The results clearly indicate that La3+/Co3O4 nanocubes improve the ascorbic acid oxidation signal
Summary
Ascorbic acid is a water soluble vitamin (vitamin C), widely present in many biological systems, fruits and vegetables. Numerous approaches such as fluorescence 9 , UV spectroscopy , chemiluminescence , electrophoresis , and liquid chromatography have been reported for the determination of ascorbic acid These methods suffer from the lack of specificity and are prone to interferences with other reducing agents in the sample. One milliliter of a vitamin C ampoule (Darou Pakhsh Company, Iran, contained 1 mg/mL of ascorbic acid) was diluted to 10 mL with 0.1 M PBS (pH 7.0); different volume of the diluted solution was transferred into each of a series of 25 mL volumetric flasks and diluted to the mark with PBS. After that 500 mg of the powder was dissolved in 25 mL water using ultrasonication and different volume of the diluted solution was transferred into a 25 mL volumetric flask and diluted to the mark with PBS (pH 7.0). The ascorbic acid content was analyzed by the proposed method using the standard addition method
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