Abstract
A sensor for the determination of antidiabetic potential of medicinal plants based on the inhibition of the α-glucosidase (AG) activity is developed using multi-walled carbon nanotubes (MWCNTs) paste electrode. The fabricated electrode was used to measure the amount of para-nitrophenol released through the hydrolysis of para-nitrophenyl-α-D-glucopyranoside (PNPG) catalyzed by AG enzyme. The enzymatic reaction is inhibited by bioactive compounds in medicinal plant extracts, which indicates the antidiabetic potential of these extract. The inhibition of the enzymatic reaction by medicinal plant extracts and Acarbose was studied by cyclic voltammetric method using the developed electrode in phosphate buffer at pH 6.8. The results show that the inhibition is higher in the presence of Tebengau (Ehretia laevis) than that in the presence of Acarbose, Cemumar (Micromelum pubescens) and Kedondong (Spondias dulcis). A good correlation was obtained between the spectrophotometric and the cyclic voltammetric methods for the measurement of the inhibition achieved with the medicinal plant extracts. Therefore, the fabricated MWCNTs paste electrode is useful for the measurement of the antidiabetic potential of medicinal plants.
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