Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines.

Abstract

An electrochemical intramolecular oxytrifluoromethylation of N-tethered alkenyl alcohols was developed providing straightforward access to CF3-containing morpholines derivatives. The method features mild reaction conditions with direct anodic oxidation of Langlois reagent as a cheap and easy to handle trifluoromethylating reagent. Variously substituted 2-(2,2,2-trifluoroethyl)morpholines were obtained in moderate to high yields under constant current electrolysis in an undivided cell.