Electrochemical glucose biosensor based on nickel oxide nanoparticle-modified carbon paste electrode

Abstract

In the present work, we designed an amperometric glucose biosensor based on nickel oxide nanoparticles (NiONPs)-modified carbon paste electrode. The biosensor was prepared by incorporation of glucose oxidase and NiONPs into a carbon paste matrix. It showed good analytical performances such as high sensitivity (367 μA mmolL–1) and a wide linear response from 1.9 × 10–3 mmolL–1 to 15.0 mmolL–1 with a limit of detection (0.11 μmolL–1). The biosensor was used for the determination of glucose in human serum samples. The results illustrate that NiONPs have enormous potential in the construction of biosensor for determination of glucose.