ELECTROCHEMICAL DETERMINATION OF KETOROLAC - A NON-OPIOID ANALGESIC AT GLASSY CARBON ELECTRODE

Suresh M Tuwar,Jayant I Gowda,Rohini M Hanabaratti

doi:10.22159/ajpcr.2019.v12i3.29914

Suresh M Tuwar, Jayant I Gowda + Show 1 more

Open Access

https://doi.org/10.22159/ajpcr.2019.v12i3.29914

Copy DOI

Abstract

Objectives: The study has been carried to investigate the electro-oxidation mechanism and to develop a selective and sensitive method for determination of ketorolac (KTL), a non-opioid analgesic drug,.Methods: A simple electro analytical method was used for the determination of ketorolac (KTL) using glassy carbon electrode by cyclic and differential pulse voltammetric techniques (DPV). The effect of various experimental parameters such as accumulation time, pH, scan rate, on the voltammetric responses of KTL was evaluated.Results: In the optimized conditions, variation of peak current with respect to concentration was studied and the calibration curve of the peak current vs. KTL concentration was drawn with a linear range of 10- 350 Î¼M with an excellent detection limit of 8.08Ã—10-8 M. This method was successfully tested for the determination of KTL in pharmaceuticals and human urine samples.Conclusion: From the results, it was observed that, the selected method is rapid, sensitive and low cost.

Highlights

IntroductionIn the past few decades, electrochemical techniques have been received considerable interest in the detection of small bio-molecules due to their high sensitivity, rapid response, simple operation, and low expense [1]
In the past few decades, electrochemical techniques have been received considerable interest in the detection of small bio-molecules due to their high sensitivity, rapid response, simple operation, and low expense [1].Ketorolac (KTL, as shown in Scheme 1) is a potent intravenous NSAID and a non-selective cyclo-oxygenase inhibitor which mediates pain, inflammation, and fever [2]
The current study describes the determination of KTL in tablets and spiked human urine samples at glassy carbon electrode (GCE)

Summary

Introduction

In the past few decades, electrochemical techniques have been received considerable interest in the detection of small bio-molecules due to their high sensitivity, rapid response, simple operation, and low expense [1]. Ketorolac (KTL, as shown in Scheme 1) is a potent intravenous NSAID and a non-selective cyclo-oxygenase inhibitor which mediates pain, inflammation, and fever [2]. It has been evaluated and used for the treatment of moderate to severe pain including post-operative pain [3]. KTL crosses the placenta and is excreted into breast milk in small quantities. The hydrophilicity and high protein binding of KTL prevent large concentrations of the drug from entering the breast milk. Administrations of KTL and other NSAIDs during the third trimester are contraindicated because they can cause premature closure of the ductus arteriosus

Objectives

Methods

Conclusion